| 4. Round | 04/02/2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Round | 08/02/2021 | Nacional | - | River Plate | 3:0 | ||||
| 6. Round | 11/02/2021 | River Plate | - | Boston River | 3:1 | ||||
| 7. Round | 14/02/2021 | Deportivo Maldonado | - | River Plate | 1:2 |  |
|||
| 8. Round | 17/02/2021 | River Plate | - | Rentistas | 1:1 | ||||
| 10. Round | 27/02/2021 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 11. Round | 06/03/2021 | Peñarol | - | River Plate | 2:0 | ||||
| 12. Round | 14/03/2021 | Liverpool | - | River Plate | 3:2 |  |
|||
| 13. Round | 20/03/2021 | River Plate | - | Montevideo City Torque | 1:1 | ||||
| 14. Round | 26/03/2021 | Plaza Colonia | - | River Plate | 1:0 | ||||
| 15. Round | 29/03/2021 | River Plate | - | Progreso | 3:2 | |
Uruguay