| 1. Round | 11/02/2022 | Estudiantes II | - | Independiente II | 3:3 | ||||
| 2. Round | 16/02/2022 | Independiente II | - | Arsenal de Sarandí II | 1:1 |  |
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| 3. Round | 20/02/2022 | Vélez Sarsfield II | - | Independiente II | 0:0 | ||||
| 4. Round | 25/02/2022 | Independiente II | - | Boca Juniors II | 1:1 | ||||
| 5. Round | 04/03/2022 | Godoy Cruz II | - | Independiente II | 0:2 | ||||
| 7. Round | 22/03/2022 | Independiente II | - | Racing Club II | 2:0 | ||||
| 8. Round | 03/04/2022 | Barracas Central II | - | Independiente II | 3:1 | ||||
| 9. Round | 07/04/2022 | Independiente II | - | Tigre II | 0:1 | ||||
| 13. Round | 29/04/2022 | Lanús II | - | Independiente II | 1:2 |
Argentina