| 1. Round | 13/08/2000 | FC Schalke 04 | - | 1. FC Köln | 2:1 | ||||
| 2. Round | 20/08/2000 | Hansa Rostock | - | FC Schalke 04 | 0:4 | ||||
| 3. Round | 05/09/2000 | FC Schalke 04 | - | Energie Cottbus | 3:0 | ||||
| 4. Round | 09/09/2000 | TSV 1860 München | - | FC Schalke 04 | 1:1 | ||||
| 5. Round | 17/09/2000 | FC Schalke 04 | - | Werder Bremen | 1:1 |  |
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| 6. Round | 23/09/2000 | Borussia Dortmund | - | FC Schalke 04 | 0:4 | |
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| 7. Round | 30/09/2000 | Hamburger SV | - | FC Schalke 04 | 2:0 | ||||
| 8. Round | 14/10/2000 | FC Schalke 04 | - | Eintracht Frankfurt | 4:0 | ||||
| 9. Round | 22/10/2000 | SC Freiburg | - | FC Schalke 04 | 3:1 | ||||
| 10. Round | 28/10/2000 | FC Schalke 04 | - | Bayer Leverkusen | 0:0 | ||||
| 26. Round | 17/03/2001 | FC Schalke 04 | - | SC Freiburg | 0:0 | ||||
| 30. Round | 21/04/2001 | FC Schalke 04 | - | Hertha BSC | 3:1 | ||||
| 31. Round | 28/04/2001 | VfL Bochum | - | FC Schalke 04 | 1:1 | ||||
| 32. Round | 05/05/2001 | FC Schalke 04 | - | VfL Wolfsburg | 2:1 | ||||
| 33. Round | 12/05/2001 | VfB Stuttgart | - | FC Schalke 04 | 1:0 | ||||
| 34. Round | 19/05/2001 | FC Schalke 04 | - | SpVgg Unterhaching | 5:3 |
Netherlands