| 6. Round | 10/09/2021 | Telstar | - | Almere City FC | 1:1 |  |
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| 9. Round | 01/10/2021 | FC Den Bosch | - | Telstar | 0:1 | ||||
| 10. Round | 18/10/2021 | Jong PSV | - | Telstar | 2:3 | ||||
| 13. Round | 01/11/2021 | Jong Ajax | - | Telstar | 3:0 | ||||
| 14. Round | 06/11/2021 | Telstar | - | SBV Excelsior | 2:5 | ||||
| 15. Round | 14/11/2021 | De Graafschap | - | Telstar | 1:1 | |
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| 16. Round | 19/11/2021 | Telstar | - | ADO Den Haag | 0:2 | |
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| 17. Round | 26/11/2021 | TOP Oss | - | Telstar | 1:1 | ||||
| 18. Round | 03/12/2021 | Telstar | - | VVV-Venlo | 1:3 |
Netherlands