| 4. Round | 31/07/2021 | Kuban Krasnodar | - | Spartak Moskva 2 | 1:2 | ||||
| 5. Round | 08/08/2021 | Alania Vladikavkaz | - | Kuban Krasnodar | 3:2 |  |
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| 6. Round | 14/08/2021 | Kuban Krasnodar | - | Tekstilshchik Ivanovo | 1:0 |  |
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| 10. Round | 11/09/2021 | Kuban Krasnodar | - | Metallurg Lipetsk | 0:3 | ||||
| 11. Round | 15/09/2021 | Baltika Kaliningrad | - | Kuban Krasnodar | 0:0 |  |
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| 13. Round | 25/09/2021 | FK Tom Tomsk | - | Kuban Krasnodar | 2:1 | ||||
| 14. Round | 29/09/2021 | Kuban Krasnodar | - | FK Orenburg | 0:1 | |
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| 15. Round | 03/10/2021 | Akron Tolyatti | - | Kuban Krasnodar | 1:0 | |
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| 17. Round | 13/10/2021 | Rotor Volgograd | - | Kuban Krasnodar | 1:3 | ||||
| 18. Round | 17/10/2021 | Kuban Krasnodar | - | FK Kamaz | 1:0 | ||||
| 19. Round | 23/10/2021 | FK Krasnodar 2 | - | Kuban Krasnodar | 1:2 | ||||
| 20. Round | 31/10/2021 | Kuban Krasnodar | - | Enisey Krasnoyarsk | 2:1 | |
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| 21. Round | 06/11/2021 | Veles Moskva | - | Kuban Krasnodar | 1:0 | ||||
| 23. Round | 17/11/2021 | Kuban Krasnodar | - | Alania Vladikavkaz | 5:5 | ||||
| 25. Round | 27/11/2021 | Kuban Krasnodar | - | Olimp-Dolgoprudny | 0:2 | |
Russia