| 12. Round | 25/09/2021 | Enisey Krasnoyarsk 2 | - | Olimp-Dolgoprudny 2 | 3:2 | ||||
| 13. Round | 30/09/2021 | Enisey Krasnoyarsk 2 | - | Torpedo Vladimir | 3:0 |  |
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| 14. Round | 04/10/2021 | FK Kazanka Moskva | - | Enisey Krasnoyarsk 2 | 1:0 | ||||
| 15. Round | 10/10/2021 | Enisey Krasnoyarsk 2 | - | Dinamo Moskva 2 | 0:2 | |
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| 16. Round | 14/10/2021 | FK Murom | - | Enisey Krasnoyarsk 2 | 3:0 | ||||
| 17. Round | 19/10/2021 | Enisey Krasnoyarsk 2 | - | FK Volna | 0:4 | ||||
| 18. Round | 25/10/2021 | FK Znamya Truda | - | Enisey Krasnoyarsk 2 | 1:1 | ||||
| 19. Round | 31/10/2021 | Enisey Krasnoyarsk 2 | - | Shinnik Yaroslavl | 1:0 | ||||
| 21. Round | 10/11/2021 | Enisey Krasnoyarsk 2 | - | FK Chertanovo | 3:0 | ||||
| 22. Round | 14/11/2021 | Enisey Krasnoyarsk 2 | - | Khimik Dzerzhinsk | 0:1 |
Russia