| 1. Round | 10/07/2021 | Spartak Moskva 2 | - | FK Krasnodar 2 | 0:0 | ||||
| 4. Round | 31/07/2021 | FK Krasnodar 2 | - | Olimp-Dolgoprudny | 2:0 | ||||
| 5. Round | 08/08/2021 | SKA-Khabarovsk | - | FK Krasnodar 2 | 1:0 | ||||
| 6. Round | 14/08/2021 | FK Krasnodar 2 | - | Volgar Astrakhan | 1:0 | ||||
| 7. Round | 21/08/2021 | Metallurg Lipetsk | - | FK Krasnodar 2 | 1:2 | ||||
| 8. Round | 29/08/2021 | Baltika Kaliningrad | - | FK Krasnodar 2 | 2:1 | ||||
| 9. Round | 05/09/2021 | Fakel Voronezh | - | FK Krasnodar 2 | 0:0 | ||||
| 12. Round | 19/09/2021 | FK Krasnodar 2 | - | Akron Tolyatti | 2:0 | ||||
| 13. Round | 25/09/2021 | FK Neftekhimik | - | FK Krasnodar 2 | 4:1 | ||||
| 21. Round | 06/11/2021 | Tekstilshchik Ivanovo | - | FK Krasnodar 2 | 0:1 | ||||
| 22. Round | 13/11/2021 | Olimp-Dolgoprudny | - | FK Krasnodar 2 | 0:1 | ||||
| 23. Round | 17/11/2021 | FK Krasnodar 2 | - | SKA-Khabarovsk | 3:1 | ||||
| 24. Round | 21/11/2021 | Volgar Astrakhan | - | FK Krasnodar 2 | 0:0 | ||||
| 25. Round | 27/11/2021 | FK Krasnodar 2 | - | Metallurg Lipetsk | 1:0 |  |
|||
| 37. Round | 14/05/2022 | Kuban Krasnodar | - | FK Krasnodar 2 | 0:0 |
Russia