| 4. Round | 07/08/2021 | Nosta Novotroitsk | - | Dinamo Barnaul | 0:2 | ||||
| 5. Round | 15/08/2021 | Volga Ulyanovsk | - | Nosta Novotroitsk | 2:1 |  |
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| 6. Round | 21/08/2021 | Lada Tolyatti | - | Nosta Novotroitsk | 2:2 | ||||
| 7. Round | 29/08/2021 | Zvezda Perm | - | Nosta Novotroitsk | 2:0 |  |
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| 8. Round | 05/09/2021 | Nosta Novotroitsk | - | Zenit Izhevsk | 1:0 | |
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| 9. Round | 12/09/2021 | Nosta Novotroitsk | - | FK Chelyabinsk | 0:3 | ||||
| 10. Round | 18/09/2021 | Nosta Novotroitsk | - | FK Tyumen | 1:1 | ||||
| 11. Round | 26/09/2021 | Nosta Novotroitsk | - | FK Novosibirsk | 0:1 | ||||
| 13. Round | 05/10/2021 | Nosta Novotroitsk | - | Torpedo Miass | 1:4 | ||||
| 14. Round | 10/10/2021 | Nosta Novotroitsk | - | FK Orenburg 2 | 3:0 | ||||
| 16. Round | 23/10/2021 | Nosta Novotroitsk | - | FK Amkar Perm | 1:0 | ||||
| 17. Round | 31/10/2021 | FK Orenburg 2 | - | Nosta Novotroitsk | 0:2 | ||||
| 18. Round | 04/11/2021 | Torpedo Miass | - | Nosta Novotroitsk | 0:3 | ||||
| 20. Round | 14/11/2021 | FK Novosibirsk | - | Nosta Novotroitsk | 2:0 | |
Russia