| 18. Round | 20/02/2022 | Victoria Rosport | - | CS FOLA Esch | 1:2 | ||||
| 19. Round | 27/02/2022 | UNA Strassen | - | Victoria Rosport | 2:2 | ||||
| 20. Round | 06/03/2022 | Victoria Rosport | - | Swift Hesperange | 0:4 | ||||
| 23. Round | 03/04/2022 | FC Wiltz 71 | - | Victoria Rosport | 1:1 |  |
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| 24. Round | 10/04/2022 | Victoria Rosport | - | F91 Dudelange | 0:5 | |
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| 25. Round | 16/04/2022 | Jeunesse Esch | - | Victoria Rosport | 2:0 | ||||
| 26. Round | 24/04/2022 | Victoria Rosport | - | US Hostert | 2:2 | ||||
| 27. Round | 30/04/2022 | RFCU Luxemburg | - | Victoria Rosport | 2:1 | ||||
| 28. Round | 06/05/2022 | Victoria Rosport | - | Union Titus Pétange | 1:1 | ||||
| 29. Round | 15/05/2022 | US Mondorf | - | Victoria Rosport | 3:1 | ||||
| 30. Round | 22/05/2022 | Victoria Rosport | - | Etzella Ettelbruck | 0:3 |
Germany