1. Round 14/08/2021 Heracles Almelo - PSV Eindhoven 0:2
2. Round 21/08/2021 Sparta Rotterdam - Heracles Almelo 1:1
3. Round 29/08/2021 Heracles Almelo - NEC Nijmegen 0:1
5. Round 19/09/2021 Heracles Almelo - AZ Alkmaar 3:2
8. Round 02/10/2021 Heracles Almelo - Willem II 3:2
9. Round 16/10/2021 Go Ahead Eagles - Heracles Almelo 4:2 yellow card
12. Round 05/11/2021 FC Twente - Heracles Almelo 1:0
13. Round 20/11/2021 Heracles Almelo - Fortuna Sittard 3:1
4. Round 01/12/2021 Feyenoord - Heracles Almelo 2:1
15. Round 04/12/2021 Heracles Almelo - sc Heerenveen 0:1
16. Round 12/12/2021 Vitesse - Heracles Almelo 2:1 Goal
17. Round 18/12/2021 Heracles Almelo - FC Groningen 4:2 Goal
18. Round 22/12/2021 Heracles Almelo - SC Cambuur 1:1 yellow card
19. Round 15/01/2022 NEC Nijmegen - Heracles Almelo 0:0
20. Round 23/01/2022 Heracles Almelo - Go Ahead Eagles 1:1
21. Round 06/02/2022 AFC Ajax - Heracles Almelo 3:0
22. Round 11/02/2022 Heracles Almelo - FC Utrecht 1:0
23. Round 19/02/2022 AZ Alkmaar - Heracles Almelo 2:1 Goal
24. Round 26/02/2022 Heracles Almelo - PEC Zwolle 2:0
25. Round 06/03/2022 PSV Eindhoven - Heracles Almelo 3:1
26. Round 13/03/2022 Heracles Almelo - Vitesse 0:0
27. Round 18/03/2022 sc Heerenveen - Heracles Almelo 2:0
28. Round 03/04/2022 Fortuna Sittard - Heracles Almelo 0:2
29. Round 10/04/2022 Heracles Almelo - Feyenoord 1:4
30. Round 24/04/2022 FC Groningen - Heracles Almelo 0:1 Goal
31. Round 30/04/2022 Heracles Almelo - FC Twente 1:1 yellow card
32. Round 07/05/2022 Willem II - Heracles Almelo 2:0
33. Round 11/05/2022 RKC Waalwijk - Heracles Almelo 2:0
34. Round 15/05/2022 Heracles Almelo - Sparta Rotterdam 1:3