| 19. Round | 11/03/2022 | Uor-5 Egorievsk [U20] | - | FK Nizhny Novgorod [U20] | 0:2 |  |
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| 20. Round | 15/03/2022 | FK Nizhny Novgorod [U20] | - | FK Khimki [U20] | 0:1 | ||||
| 21. Round | 01/04/2022 | Arsenal Tula [U20] | - | FK Nizhny Novgorod [U20] | 1:2 | ||||
| 23. Round | 15/04/2022 | FK Krasnodar [U20] | - | FK Nizhny Novgorod [U20] | 4:0 | ||||
| 24. Round | 22/04/2022 | FK Nizhny Novgorod [U20] | - | Uor-5 Egorievsk [U20] | 3:2 | |
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| 25. Round | 29/04/2022 | FK Khimki [U20] | - | FK Nizhny Novgorod [U20] | 1:0 | ||||
| 26. Round | 06/05/2022 | FK Nizhny Novgorod [U20] | - | Arsenal Tula [U20] | 3:1 | |
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| 27. Round | 13/05/2022 | Akhmat Grozny [U20] | - | FK Nizhny Novgorod [U20] | 1:0 | ||||
| 22. Round | 17/05/2022 | FK Nizhny Novgorod [U20] | - | Akhmat Grozny [U20] | 1:0 | ||||
| 28. Round | 20/05/2022 | FK Nizhny Novgorod [U20] | - | FK Krasnodar [U20] | 0:3 |
Russia