| 19. Round | 13/02/2022 | Makedonija GP | - | GFK Tikvesh | 1:0 |  |
|||
| 20. Round | 20/02/2022 | GFK Tikvesh | - | FK Pelister | 1:0 | ||||
| 21. Round | 27/02/2022 | KF Shkupi | - | GFK Tikvesh | 3:2 | ||||
| 22. Round | 05/03/2022 | GFK Tikvesh | - | FK Skopje | 3:0 | ||||
| 23. Round | 13/03/2022 | KF Shkëndija 79 | - | GFK Tikvesh | 2:1 | ||||
| 24. Round | 19/03/2022 | GFK Tikvesh | - | FK AP Brera Strumica | 1:2 | |
|||
| 25. Round | 03/04/2022 | KF Shkupi | - | GFK Tikvesh | 1:0 | ||||
| 26. Round | 06/04/2022 | GFK Tikvesh | - | FC Struga | 2:0 | |
|||
| 27. Round | 10/04/2022 | FK Rabotnički | - | GFK Tikvesh | 1:0 | ||||
| 28. Round | 17/04/2022 | FK Skopje | - | GFK Tikvesh | 1:2 | ||||
| 29. Round | 23/04/2022 | GFK Tikvesh | - | FK Borec | 5:0 | |
|||
| 30. Round | 01/05/2022 | FK Pelister | - | GFK Tikvesh | 1:1 | |
|||
| 32. Round | 08/05/2022 | FK Bregalnica Štip | - | GFK Tikvesh | 1:0 | ||||
| 33. Round | 15/05/2022 | GFK Tikvesh | - | Makedonija GP | 2:1 |  |
Bulgaria