| 1. Round | 13/09/2021 | Aris Saloniki | - | OFI Heraklion | 0:0 | ||||
| 2. Round | 19/09/2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
| 3. Round | 22/09/2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
| 4. Round | 27/09/2021 | PAS Giannina | - | OFI Heraklion | 1:1 | ||||
| 5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
| 13. Round | 12/01/2022 | Apollon Smyrnis | - | OFI Heraklion | 0:3 | ||||
| 25. Round | 27/02/2022 | Olympiakos Piraeus | - | OFI Heraklion | 2:0 |
Greece