| 1. Round | 11/09/2021 | Panetolikos | - | Asteras Tripolis | 0:0 | ||||
| 2. Round | 19/09/2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
| 3. Round | 22/09/2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
| 4. Round | 26/09/2021 | Asteras Tripolis | - | Olympiakos Piraeus | 0:2 | ||||
| 5. Round | 02/10/2021 | Volos NFC | - | Asteras Tripolis | 2:1 | ||||
| 14. Round | 14/12/2021 | Asteras Tripolis | - | Panetolikos | 1:0 | ||||
| 16. Round | 04/01/2022 | Asteras Tripolis | - | OFI Heraklion | 1:0 | ||||
| 18. Round | 15/01/2022 | Asteras Tripolis | - | Volos NFC | 1:0 | ||||
| 19. Round | 24/01/2022 | Asteras Tripolis | - | Apollon Smyrnis | 1:0 |  |
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| 22. Round | 23/02/2022 | Lamia | - | Asteras Tripolis | 0:2 | ||||
| 25. Round | 26/02/2022 | Asteras Tripolis | - | Aris Saloniki | 0:2 | ||||
| 26. Round | 06/03/2022 | AEK Athen | - | Asteras Tripolis | 2:1 |
Greece