| 7. Round | 12/09/2010 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 8. Round | 19/09/2010 | Club San Luis | - | CF Pachuca | 1:0 |  |
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| 10. Round | 03/10/2010 | Club San Luis | - | UANL Tigres | 1:0 | ||||
| 11. Round | 10/10/2010 | Atlas Guadalajara | - | Club San Luis | 2:1 | ||||
| 13. Round | 23/10/2010 | Club Necaxa | - | Club San Luis | 0:2 | ||||
| 15. Round | 31/10/2010 | Deportivo Toluca | - | Club San Luis | 1:2 | ||||
| 16. Round | 06/11/2010 | Club San Luis | - | Santos Laguna | 1:1 | |
Mexico