| 4. Round | 30/01/2011 | Monarcas Morelia | - | Club San Luis | 3:3 | ||||
| 14. Round | 03/02/2011 | CF América | - | Club San Luis | 3:0 | ||||
| 5. Round | 06/02/2011 | Club San Luis | - | Estudiantes Tecos | 3:2 | ||||
| 6. Round | 13/02/2011 | Atlante | - | Club San Luis | 0:0 | ||||
| 8. Round | 27/02/2011 | CF Pachuca | - | Club San Luis | 0:0 | ||||
| 9. Round | 06/03/2011 | Club San Luis | - | Jaguares Chiapas | 0:0 | ||||
| 10. Round | 13/03/2011 | UANL Tigres | - | Club San Luis | 1:1 | ||||
| 12. Round | 03/04/2011 | Gallos Blancos (old) | - | Club San Luis | 3:2 | ||||
| 15. Round | 17/04/2011 | Club San Luis | - | Deportivo Toluca | 1:2 | ||||
| 16. Round | 24/04/2011 | Santos Laguna | - | Club San Luis | 1:3 | ||||
| 17. Round | 01/05/2011 | Club San Luis | - | Cruz Azul | 0:0 |
Mexico