| 8. Round | 08/11/2020 | Zitácuaro | - | Club Irapuato | 0:0 | ||||
| 9. Round | 13/11/2020 | Club Irapuato | - | Azores de Hidalgo | 5:0 | ||||
| 2. Round | 18/11/2020 | CD Cuautla | - | Club Irapuato | 1:3 |  |
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| 11. Round | 27/11/2020 | Inter Playa | - | Club Irapuato | 2:0 | |
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| 7. Round | 02/12/2020 | Club Irapuato | - | Cafetaleros de Chiapas | 4:2 | ||||
| 12. Round | 06/12/2020 | Club Irapuato | - | Club de Ciervos | 0:0 | ||||
| 13. Round | 11/12/2020 | Cañoneros Marina | - | Club Irapuato | 1:2 |  |
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| 1. Round | 16/12/2020 | Club Irapuato | - | Cruz Azul Hidalgo | 0:2 | ||||
| 14. Round | 16/01/2021 | Cruz Azul Hidalgo | - | Club Irapuato | 2:2 | ||||
| 18. Round | 12/02/2021 | Pioneros de Cancún | - | Club Irapuato | 0:3 | ||||
| 20. Round | 01/03/2021 | Cafetaleros de Chiapas | - | Club Irapuato | 0:0 | ||||
| 21. Round | 07/03/2021 | Club Irapuato | - | Zitácuaro | 2:1 | ||||
| 22. Round | 14/03/2021 | Azores de Hidalgo | - | Club Irapuato | 1:4 | ||||
| 15. Round | 17/03/2021 | Club Irapuato | - | CD Cuautla | 2:1 | ||||
| 24. Round | 26/03/2021 | Club Irapuato | - | Inter Playa | 1:0 | ||||
| 25. Round | 03/04/2021 | Club de Ciervos | - | Club Irapuato | 0:3 | ||||
| 26. Round | 09/04/2021 | Club Irapuato | - | Cañoneros Marina | 6:0 |
Mexico