| 1. Round | 22/08/2021 | AS Béziers [Youth] | - | AS Saint-Étienne [Youth] | 2:6 | ||||
| 2. Round | 29/08/2021 | AS Saint-Étienne [Youth] | - | Pieve di Lota [Youth] | 11:0 | ||||
| 3. Round | 05/09/2021 | SC Toulon [Youth] | - | AS Saint-Étienne [Youth] | 1:1 | ||||
| 4. Round | 12/09/2021 | AS Saint-Étienne [Youth] | - | AS Monaco [Youth] | 2:0 | ||||
| 9. Round | 16/10/2021 | OGC Nice [Youth] | - | AS Saint-Étienne [Youth] | 4:3 | ||||
| 10. Round | 23/10/2021 | AS Saint-Étienne [Youth] | - | Nîmes Olympique [Youth] | 2:0 | ||||
| 14. Round | 05/12/2021 | Pieve di Lota [Youth] | - | AS Saint-Étienne [Youth] | 1:7 | ||||
| 13. Round | 19/12/2021 | AS Saint-Étienne [Youth] | - | FC Istres [Youth] | 0:1 | ||||
| 15. Round | 16/01/2022 | AS Saint-Étienne [Youth] | - | SC Toulon [Youth] | 4:2 | ||||
| 17. Round | 06/02/2022 | AS Saint-Étienne [Youth] | - | Olympique Marseille [Youth] | 3:1 | ||||
| 18. Round | 13/02/2022 | US Colomiers [Youth] | - | AS Saint-Étienne [Youth] | 0:0 | ||||
| 19. Round | 06/03/2022 | AS Saint-Étienne [Youth] | - | AS Cannes [Youth] | 6:3 | ||||
| 23. Round | 10/04/2022 | AS Saint-Étienne [Youth] | - | Toulouse FC [Youth] | 0:0 |
France