| 1. Round | 14/08/2005 | FC Groningen | - | RBC Roosendaal | 1:0 | ||||
| 2. Round | 20/08/2005 | RBC Roosendaal | - | AFC Ajax | 0:2 | ||||
| 3. Round | 28/08/2005 | RBC Roosendaal | - | Willem II | 1:1 | ||||
| 4. Round | 10/09/2005 | AZ Alkmaar | - | RBC Roosendaal | 7:0 | ||||
| 5. Round | 17/09/2005 | RBC Roosendaal | - | Sparta Rotterdam | 1:1 |  |
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| 6. Round | 24/09/2005 | PSV Eindhoven | - | RBC Roosendaal | 2:0 | ||||
| 7. Round | 30/09/2005 | RBC Roosendaal | - | NAC Breda | 1:2 | ||||
| 8. Round | 16/10/2005 | NEC Nijmegen | - | RBC Roosendaal | 3:1 | ||||
| 9. Round | 22/10/2005 | RBC Roosendaal | - | Vitesse | 0:3 | ||||
| 13. Round | 27/11/2005 | sc Heerenveen | - | RBC Roosendaal | 2:0 | ||||
| 15. Round | 10/12/2005 | ADO Den Haag | - | RBC Roosendaal | 3:0 |  |
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| 16. Round | 17/12/2005 | RBC Roosendaal | - | Roda JC Kerkrade | 0:2 | ||||
| 17. Round | 26/12/2005 | FC Twente | - | RBC Roosendaal | 4:1 | ||||
| 18. Round | 29/12/2005 | RBC Roosendaal | - | FC Utrecht | 1:2 | ||||
| 22. Round | 03/02/2006 | Willem II | - | RBC Roosendaal | 3:1 | |
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| 23. Round | 07/02/2006 | RBC Roosendaal | - | AZ Alkmaar | 0:5 |
Netherlands