| 1. Round | 01/07/2022 | Mazatlán FC [U20] | - | Puebla FC [U20] | 0:2 |  |
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| 3. Round | 18/07/2022 | CF Pachuca [U20] | - | Mazatlán FC [U20] | 2:1 |  |
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| 4. Round | 22/07/2022 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 5:0 | ||||
| 5. Round | 27/07/2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 5:0 | |
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| 9. Round | 16/08/2022 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 0:1 | ||||
| 10. Round | 19/08/2022 | FC Juárez [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 11. Round | 26/08/2022 | Mazatlán FC [U20] | - | CF América [U20] | 4:4 | |
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| 12. Round | 03/09/2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 16. Round | 24/09/2022 | Club Necaxa [U20] | - | Mazatlán FC [U20] | 2:0 | ||||
| 8. Round | 27/09/2022 | Club León [U20] | - | Mazatlán FC [U20] | 4:1 | ||||
| 17. Round | 02/10/2022 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 2:3 |
Mexico