| 2. Round | 17/07/2021 | Rotor Volgograd | - | Olimp-Dolgoprudny | 1:1 | ||||
| 3. Round | 24/07/2021 | Rotor Volgograd | - | SKA-Khabarovsk | 0:0 | ||||
| 4. Round | 31/07/2021 | Rotor Volgograd | - | Volgar Astrakhan | 1:1 |  |
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| 6. Round | 14/08/2021 | Rotor Volgograd | - | Baltika Kaliningrad | 1:1 | ||||
| 7. Round | 21/08/2021 | Fakel Voronezh | - | Rotor Volgograd | 1:0 | ||||
| 8. Round | 29/08/2021 | FK Tom Tomsk | - | Rotor Volgograd | 1:1 | ||||
| 17. Round | 13/10/2021 | Rotor Volgograd | - | Kuban Krasnodar | 1:3 | ||||
| 18. Round | 17/10/2021 | Spartak Moskva 2 | - | Rotor Volgograd | 1:1 | ||||
| 19. Round | 23/10/2021 | Rotor Volgograd | - | Alania Vladikavkaz | 0:0 | ||||
| 21. Round | 06/11/2021 | SKA-Khabarovsk | - | Rotor Volgograd | 3:1 | ||||
| 23. Round | 17/11/2021 | Rotor Volgograd | - | Metallurg Lipetsk | 0:1 | ||||
| 24. Round | 21/11/2021 | Baltika Kaliningrad | - | Rotor Volgograd | 2:1 | |
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| 25. Round | 27/11/2021 | Rotor Volgograd | - | Fakel Voronezh | 1:2 |
Ukraine