| 2. Round | 17/07/2010 | PFK Sevastopol | - | Metalist Kharkiv | 0:0 | ||||
| 3. Round | 24/07/2010 | Arsenal Kiev | - | PFK Sevastopol | 0:1 | ||||
| 7. Round | 22/08/2010 | Karpaty Lviv | - | PFK Sevastopol | 2:1 | ||||
| 8. Round | 27/08/2010 | PFK Sevastopol | - | Vorskla Poltava | 0:0 | ||||
| 9. Round | 10/09/2010 | Volyn Lutsk | - | PFK Sevastopol | 1:0 | ||||
| 10. Round | 18/09/2010 | PFK Sevastopol | - | Dnipro Dnipropetrovsk | 2:1 | ||||
| 13. Round | 16/10/2010 | FK Obolon | - | PFK Sevastopol | 2:2 | ||||
| 14. Round | 23/10/2010 | PFK Sevastopol | - | Metalurg Zaporizhya | 1:0 | ||||
| 16. Round | 06/11/2010 | PFK Sevastopol | - | Zorya Lugansk | 0:1 | ||||
| 17. Round | 13/11/2010 | Metalist Kharkiv | - | PFK Sevastopol | 4:0 | ||||
| 18. Round | 19/11/2010 | PFK Sevastopol | - | Arsenal Kiev | 0:2 |
Ukraine