| 1. Round | 10/07/2021 | Kuban Krasnodar | - | Torpedo Moskva | 1:2 | ||||
| 3. Round | 25/07/2021 | Kuban Krasnodar | - | Veles Moskva | 0:2 | ||||
| 4. Round | 31/07/2021 | Kuban Krasnodar | - | Spartak Moskva 2 | 1:2 |  |
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| 5. Round | 08/08/2021 | Alania Vladikavkaz | - | Kuban Krasnodar | 3:2 | ||||
| 6. Round | 14/08/2021 | Kuban Krasnodar | - | Tekstilshchik Ivanovo | 1:0 | |
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| 7. Round | 21/08/2021 | Olimp-Dolgoprudny | - | Kuban Krasnodar | 1:0 | ||||
| 9. Round | 05/09/2021 | Volgar Astrakhan | - | Kuban Krasnodar | 0:2 | ||||
| 10. Round | 11/09/2021 | Kuban Krasnodar | - | Metallurg Lipetsk | 0:3 | ||||
| 11. Round | 15/09/2021 | Baltika Kaliningrad | - | Kuban Krasnodar | 0:0 | |
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| 12. Round | 19/09/2021 | Kuban Krasnodar | - | Fakel Voronezh | 0:4 | |
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| 22. Round | 13/11/2021 | Spartak Moskva 2 | - | Kuban Krasnodar | 0:0 | ||||
| 23. Round | 17/11/2021 | Kuban Krasnodar | - | Alania Vladikavkaz | 5:5 | ||||
| 24. Round | 21/11/2021 | Tekstilshchik Ivanovo | - | Kuban Krasnodar | 1:3 |  |
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| 25. Round | 27/11/2021 | Kuban Krasnodar | - | Olimp-Dolgoprudny | 0:2 |
Russia