| 21. Round | 03/04/2022 | FK Novosibirsk | - | FK Amkar Perm | 4:0 |  |
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| 22. Round | 09/04/2022 | FK Novosibirsk | - | Zenit Izhevsk | 2:0 | ||||
| 23. Round | 17/04/2022 | Volga Ulyanovsk | - | FK Novosibirsk | 1:1 | |
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| 24. Round | 21/04/2022 | Lada Tolyatti | - | FK Novosibirsk | 0:4 | ||||
| 25. Round | 30/04/2022 | FK Novosibirsk | - | Torpedo Miass | 0:0 | ||||
| 26. Round | 08/05/2022 | FK Novosibirsk | - | Spartak Tuymazy | 5:1 | |
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| 27. Round | 15/05/2022 | FK Chelyabinsk | - | FK Novosibirsk | 2:0 | ||||
| 30. Round | 04/06/2022 | FK Novosibirsk | - | Zvezda Perm | 1:2 |
Russia