| 1. Round | 25/07/2021 | Zorya Lugansk | - | FK Oleksandriya | 0:1 | ||||
| 2. Round | 31/07/2021 | FC Mynai | - | FK Oleksandriya | 1:0 | ||||
| 3. Round | 07/08/2021 | Shakhtar Donetsk | - | FK Oleksandriya | 1:2 | ||||
| 4. Round | 15/08/2021 | FK Lviv | - | FK Oleksandriya | 1:1 | ||||
| 5. Round | 22/08/2021 | Kolos Kovalivka | - | FK Oleksandriya | 0:1 |  |
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| 6. Round | 27/08/2021 | Chernomorets Odessa | - | FK Oleksandriya | 2:2 | ||||
| 7. Round | 10/09/2021 | FK Oleksandriya | - | Inhulets Petrove | 1:0 | ||||
| 9. Round | 25/09/2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | ||||
| 12. Round | 22/10/2021 | Desna Chernigov | - | FK Oleksandriya | 1:1 | ||||
| 13. Round | 31/10/2021 | Rukh Lviv | - | FK Oleksandriya | 0:0 | |
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| 14. Round | 05/11/2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 15. Round | 20/11/2021 | SK Dnipro-1 | - | FK Oleksandriya | 3:1 | ||||
| 16. Round | 29/11/2021 | FK Oleksandriya | - | Zorya Lugansk | 0:1 | ||||
| 17. Round | 05/12/2021 | FK Oleksandriya | - | FC Mynai | 3:0 |
Ukraine