| 2. Round | 12/09/2020 | Kolos Kovalivka | - | FK Lviv | 4:0 | ||||
| 3. Round | 19/09/2020 | Dinamo Kiev | - | FK Lviv | 3:1 | ||||
| 4. Round | 27/09/2020 | FK Lviv | - | Zorya Lugansk | 0:5 | ||||
| 10. Round | 22/11/2020 | Desna Chernigov | - | FK Lviv | 0:1 | ||||
| 11. Round | 27/11/2020 | FK Lviv | - | FK Mariupol | 1:3 |  |
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| 12. Round | 05/12/2020 | FK Lviv | - | Inhulets Petrove | 1:1 | ||||
| 13. Round | 11/12/2020 | Olimpik Donetsk | - | FK Lviv | 1:1 | ||||
| 15. Round | 20/02/2021 | FK Lviv | - | Kolos Kovalivka | 0:2 | ||||
| 16. Round | 28/02/2021 | FK Lviv | - | Dinamo Kiev | 1:4 | ||||
| 17. Round | 07/03/2021 | Zorya Lugansk | - | FK Lviv | 4:0 | |
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| 19. Round | 21/03/2021 | FK Lviv | - | Shakhtar Donetsk | 3:2 | ||||
| 20. Round | 02/04/2021 | SK Dnipro-1 | - | FK Lviv | 5:1 | |
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| 21. Round | 11/04/2021 | Vorskla Poltava | - | FK Lviv | 2:1 | ||||
| 22. Round | 16/04/2021 | FK Lviv | - | FK Oleksandriya | 3:1 | ||||
| 1. Round | 21/04/2021 | FK Lviv | - | FC Mynai | 1:0 | |
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| 18. Round | 28/04/2021 | FK Lviv | - | Rukh Lviv | 1:1 | ||||
| 24. Round | 02/05/2021 | FK Mariupol | - | FK Lviv | 1:2 | |
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| 25. Round | 06/05/2021 | Inhulets Petrove | - | FK Lviv | 1:0 | |
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| 26. Round | 09/05/2021 | FK Lviv | - | Olimpik Donetsk | 1:1 |
Ukraine