| 1. Round | 23/07/2021 | FK Lviv | - | FK Mariupol | 1:1 | ||||
| 2. Round | 30/07/2021 | FK Lviv | - | Shakhtar Donetsk | 0:3 | ||||
| 3. Round | 08/08/2021 | Vorskla Poltava | - | FK Lviv | 4:1 |  |
|||
| 4. Round | 15/08/2021 | FK Lviv | - | FK Oleksandriya | 1:1 | ||||
| 6. Round | 29/08/2021 | Rukh Lviv | - | FK Lviv | 1:0 | |
|||
| 7. Round | 13/09/2021 | NK Veres | - | FK Lviv | 1:0 | ||||
| 8. Round | 19/09/2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | |
|||
| 9. Round | 26/09/2021 | FC Mynai | - | FK Lviv | 1:2 | ||||
| 10. Round | 02/10/2021 | FK Lviv | - | SK Dnipro-1 | 0:1 | |
|||
| 12. Round | 23/10/2021 | Chernomorets Odessa | - | FK Lviv | 1:1 | ||||
| 13. Round | 31/10/2021 | Kolos Kovalivka | - | FK Lviv | 0:1 |  |
|
||
| 14. Round | 07/11/2021 | FK Lviv | - | Desna Chernigov | 0:2 |  |
|||
| 17. Round | 03/12/2021 | Shakhtar Donetsk | - | FK Lviv | 6:1 | ||||
| 18. Round | 11/12/2021 | FK Lviv | - | Vorskla Poltava | 1:1 |
Ukraine