| 1. Round | 26/07/2021 | Vorskla Poltava | - | SK Dnipro-1 | 2:2 | ||||
| 2. Round | 31/07/2021 | Chernomorets Odessa | - | SK Dnipro-1 | 0:3 | ||||
| 3. Round | 07/08/2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 | ||||
| 4. Round | 14/08/2021 | Desna Chernigov | - | SK Dnipro-1 | 2:1 | ||||
| 5. Round | 21/08/2021 | SK Dnipro-1 | - | Rukh Lviv | 2:0 | ||||
| 6. Round | 28/08/2021 | Metalist 1925 Kharkiv | - | SK Dnipro-1 | 1:2 | ||||
| 7. Round | 11/09/2021 | Shakhtar Donetsk | - | SK Dnipro-1 | 2:0 |  |
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| 8. Round | 18/09/2021 | SK Dnipro-1 | - | NK Veres | 1:0 | |
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| 9. Round | 26/09/2021 | SK Dnipro-1 | - | Zorya Lugansk | 0:4 | ||||
| 10. Round | 02/10/2021 | FK Lviv | - | SK Dnipro-1 | 0:1 | ||||
| 11. Round | 16/10/2021 | SK Dnipro-1 | - | Kolos Kovalivka | 2:0 | ||||
| 12. Round | 24/10/2021 | Dinamo Kiev | - | SK Dnipro-1 | 2:0 | ||||
| 13. Round | 01/11/2021 | SK Dnipro-1 | - | FC Mynai | 4:0 | ||||
| 14. Round | 07/11/2021 | Inhulets Petrove | - | SK Dnipro-1 | 0:1 | ||||
| 15. Round | 20/11/2021 | SK Dnipro-1 | - | FK Oleksandriya | 3:1 | |
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| 16. Round | 27/11/2021 | SK Dnipro-1 | - | Vorskla Poltava | 5:1 | ||||
| 17. Round | 06/12/2021 | SK Dnipro-1 | - | Chernomorets Odessa | 3:1 | ||||
| 18. Round | 10/12/2021 | FK Mariupol | - | SK Dnipro-1 | 0:3 |
Ukraine