| 21. Round | 27/02/2022 | PS Kalamata | - | AE Karaiskakis | 2:0 | ||||
| 22. Round | 05/03/2022 | AE Karaiskakis | - | Panathinaikos II | 1:1 | ||||
| 24. Round | 13/03/2022 | Ergotelis | - | AE Karaiskakis | 0:0 | ||||
| 25. Round | 20/03/2022 | AE Karaiskakis | - | Asteras Vlachioti | 0:1 | ||||
| 26. Round | 26/03/2022 | Diagoras FC | - | AE Karaiskakis | 0:1 | ||||
| 27. Round | 30/03/2022 | AE Karaiskakis | - | PAE Chania | 1:2 | ||||
| 29. Round | 06/04/2022 | AE Karaiskakis | - | OFI Ierapetra | 2:3 | ||||
| 30. Round | 10/04/2022 | GS Kallithea | - | AE Karaiskakis | 4:2 | ||||
| 31. Round | 13/04/2022 | AE Karaiskakis | - | AO Egaleo | 3:1 | ||||
| 32. Round | 17/04/2022 | Irodotos | - | AE Karaiskakis | 0:0 | ||||
| 33. Round | 27/04/2022 | AE Karaiskakis | - | Levadiakos | 0:3 |
Ukraine