| 5. Round | 08/08/2021 | San Diego Loyal | - | Real Monarchs SLC | 0:1 | ||||
| 5. Round | 15/08/2021 | San Diego Loyal | - | Tacoma Defiance | 1:2 | ||||
| 5. Round | 19/08/2021 | San Diego Loyal | - | Las Vegas Lights FC | 5:1 | ||||
| 5. Round | 22/08/2021 | San Diego Loyal | - | Orange County SC | 1:2 | ||||
| 5. Round | 29/08/2021 | Sacramento Republic | - | San Diego Loyal | 1:3 |  |
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| 6. Round | 05/09/2021 | San Diego Loyal | - | Los Angeles Galaxy II | 4:2 | ||||
| 6. Round | 12/09/2021 | Oakland Roots | - | San Diego Loyal | 0:0 | ||||
| 7. Round | 17/10/2021 | San Diego Loyal | - | New Mexico United | 1:1 | ||||
| 7. Round | 21/10/2021 | Orange County SC | - | San Diego Loyal | 1:0 | ||||
| 7. Round | 24/10/2021 | San Diego Loyal | - | Oakland Roots | 3:4 | ||||
| 7. Round | 31/10/2021 | Sacramento Republic | - | San Diego Loyal | 1:1 |
USA