| 2. Round | 01/08/2021 | Nykøbing FC | - | FC Fredericia | 4:4 | ||||
| 3. Round | 09/08/2021 | Jammerbugt FC | - | FC Fredericia | 0:3 |  |
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| 4. Round | 13/08/2021 | FC Fredericia | - | Hvidovre IF | 1:0 | ||||
| 5. Round | 17/08/2021 | FC Fredericia | - | Esbjerg fB | 1:0 | ||||
| 6. Round | 22/08/2021 | Vendsyssel FF | - | FC Fredericia | 1:1 |  |
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| 7. Round | 27/08/2021 | FC Fredericia | - | Fremad Amager | 2:1 | |
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| 8. Round | 12/09/2021 | AC Horsens | - | FC Fredericia | 1:3 | ||||
| 9. Round | 17/09/2021 | FC Fredericia | - | FC Helsingør | 2:4 | ||||
| 11. Round | 01/10/2021 | FC Fredericia | - | Lyngby BK | 0:2 | ||||
| 12. Round | 15/10/2021 | Fremad Amager | - | FC Fredericia | 0:1 | |
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| 13. Round | 23/10/2021 | Esbjerg fB | - | FC Fredericia | 1:2 | ||||
| 14. Round | 31/10/2021 | FC Fredericia | - | Vendsyssel FF | 4:0 | ||||
| 15. Round | 08/11/2021 | FC Helsingør | - | FC Fredericia | 4:1 | ||||
| 16. Round | 21/11/2021 | FC Fredericia | - | Nykøbing FC | 3:2 | |
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| 17. Round | 27/11/2021 | Hvidovre IF | - | FC Fredericia | 5:1 | |
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| 19. Round | 26/02/2022 | Lyngby BK | - | FC Fredericia | 1:1 | |
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| 20. Round | 06/03/2022 | FC Fredericia | - | Jammerbugt FC | 3:0 | ||||
| 21. Round | 11/03/2022 | Hobro IK | - | FC Fredericia | 3:1 | ||||
| 22. Round | 18/03/2022 | FC Fredericia | - | HB Køge | 2:2 |
Denmark