| 21. Round | 15/01/2022 | VfL Osnabrück | - | 1. FC Saarbrücken | 2:1 | ||||
| 22. Round | 22/01/2022 | SV Wehen Wiesbaden | - | VfL Osnabrück | 0:0 | ||||
| 24. Round | 29/01/2022 | Borussia Dortmund II | - | VfL Osnabrück | 2:2 | ||||
| 25. Round | 05/02/2022 | VfL Osnabrück | - | Türkgücü München | annull. | ||||
| 29. Round | 05/03/2022 | VfL Osnabrück | - | 1. FC Kaiserslautern | 0:1 | ||||
| 31. Round | 19/03/2022 | VfL Osnabrück | - | FC Viktoria 1889 Berlin | 3:1 | ||||
| 27. Round | 26/03/2022 | VfL Osnabrück | - | Eintracht Braunschweig | 1:1 | ||||
| 33. Round | 11/04/2022 | VfL Osnabrück | - | SC Verl | 3:2 | ||||
| 32. Round | 19/04/2022 | Hallescher FC | - | VfL Osnabrück | 3:3 |  |
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| 36. Round | 30/04/2022 | SC Freiburg II | - | VfL Osnabrück | 4:1 | ||||
| 37. Round | 07/05/2022 | TSV Havelse | - | VfL Osnabrück | 0:1 | ||||
| 38. Round | 14/05/2022 | VfL Osnabrück | - | 1. FC Magdeburg | 1:5 |
Germany
England