| 2. Round | 02/05/2021 | San Antonio FC | - | Colorado Springs Switchbacks | 3:0 | ||||
| 2. Round | 09/05/2021 | San Antonio FC | - | Real Monarchs SLC | 2:2 | ||||
| 2. Round | 17/05/2021 | Rio Grande Valley FC | - | San Antonio FC | 2:1 | ||||
| 3. Round | 06/06/2021 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 3. Round | 12/06/2021 | Las Vegas Lights FC | - | San Antonio FC | 1:1 | ||||
| 3. Round | 17/06/2021 | New Mexico United | - | San Antonio FC | 2:0 | ||||
| 3. Round | 20/06/2021 | San Antonio FC | - | Rio Grande Valley FC | 1:1 | ||||
| 3. Round | 27/06/2021 | Real Monarchs SLC | - | San Antonio FC | 1:1 | ||||
| 4. Round | 04/07/2021 | San Antonio FC | - | Austin Bold | 0:1 | ||||
| 4. Round | 29/07/2021 | San Antonio FC | - | El Paso Locomotive | 1:2 | ||||
| 5. Round | 09/08/2021 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | ||||
| 6. Round | 08/09/2021 | Austin Bold | - | San Antonio FC | 2:1 | ||||
| 7. Round | 11/10/2021 | San Antonio FC | - | Memphis 901 | 4:2 | ||||
| 7. Round | 21/10/2021 | New Mexico United | - | San Antonio FC | 4:2 |  |
England