| 1. Round | 15/08/2021 | Southampton FC U23 | - | Norwich City U23 | 0:3 | ||||
| 2. Round | 23/08/2021 | Nottingham Forest U23 | - | Southampton FC U23 | 0:0 | ||||
| 3. Round | 29/08/2021 | Middlesbrough FC U23 | - | Southampton FC U23 | 2:1 |  |
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| 6. Round | 27/09/2021 | Birmingham City U23 | - | Southampton FC U23 | 3:2 | ||||
| 7. Round | 01/10/2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
| 8. Round | 18/10/2021 | Wolverhampton Wanderers U23 | - | Southampton FC U23 | 0:1 | ||||
| 9. Round | 25/10/2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 10. Round | 31/10/2021 | Southampton FC U23 | - | Aston Villa U23 | 4:0 | ||||
| 11. Round | 05/11/2021 | Southampton FC U23 | - | Newcastle United U23 | 5:0 | ||||
| 12. Round | 21/11/2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | ||||
| 13. Round | 28/11/2021 | Southampton FC U23 | - | West Bromwich Albion U23 | 3:1 |  |
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| 14. Round | 06/12/2021 | Stoke City U23 | - | Southampton FC U23 | 3:0 | ||||
| 19. Round | 07/02/2022 | West Bromwich Albion U23 | - | Southampton FC U23 | 0:1 |
England
Nigeria