| 1° División | 23/01/21 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
| 1° División | 15/02/21 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 1° División | 14/03/21 | Club Tijuana | - | Santos Laguna | 0:1 | ||||
| 1° División | 17/05/21 | CF Monterrey | - | Santos Laguna | 1:1 | ||||
| 1° División | 20/09/21 | Santos Laguna | - | Puebla FC | 1:1 | ||||
| 1° División | 21/11/21 | Santos Laguna | - | Atlético San Luis | 2:0 | ||||
| 1° División | 16/01/22 | Deportivo Toluca | - | Santos Laguna | 3:1 | ||||
| 1° División | 09/07/22 | Puebla FC | - | Santos Laguna | 1:0 | ||||
| 1° División | 01/08/22 | Santos Laguna | - | Atlas Guadalajara | 1:0 | ||||
| 1° División | 21/01/23 | Mazatlán FC | - | Santos Laguna | 1:2 |  |
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| 1° División | 22/10/23 | CF América | - | Santos Laguna | 4:3 | ||||
| 1° División | 27/11/23 | Club León | - | Santos Laguna | 3:2 | ||||
| 31/07/24 | Los Angeles FC | - | Vancouver Whitecaps | 2:4 pso | |||||
| 18/08/24 | Seattle Sounders | - | Los Angeles FC | 0:3 | |||||
| 1° División | 09/02/25 | Cruz Azul | - | CF Pachuca | 2:1 | ||||
| 1° División | 09/05/25 | Club León | - | Cruz Azul | 2:3 |
Mexico