| 1° División | 24/07/21 | Club Necaxa | - | Santos Laguna | 0:3 | ||||
| 1° División | 30/10/21 | Gallos Blancos | - | Santos Laguna | 2:3 |  |
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| 1° División | 26/11/21 | Santos Laguna | - | UANL Tigres | 2:1 | ||||
| 1° División | 07/02/22 | Atlas Guadalajara | - | Santos Laguna | 2:1 | ||||
| 1° División | 04/07/22 | Santos Laguna | - | CF Monterrey | 4:3 |
Mexico