1. Round | 20/01/2022 | Club León | - | Atlas Guadalajara | 1:1 | ||||
4. Round | 08/02/2022 | Club León | - | Cruz Azul | 0:1 | ||||
5. Round | 13/02/2022 | Pumas UNAM | - | Club León | 2:1 | ||||
6. Round | 20/02/2022 | Club León | - | Deportivo Guadalajara | 2:1 | ||||
7. Round | 26/02/2022 | Club Necaxa | - | Club León | 0:1 | ||||
12. Round | 03/04/2022 | Club León | - | Gallos Blancos | 1:1 | ||||
13. Round | 09/04/2022 | Atlético San Luis | - | Club León | 2:0 | ||||
14. Round | 16/04/2022 | Club León | - | Puebla FC | 0:1 | ||||
15. Round | 21/04/2022 | CF América | - | Club León | 2:0 | ||||
16. Round | 25/04/2022 | Santos Laguna | - | Club León | 1:1 | ||||
17. Round | 02/05/2022 | Club León | - | Deportivo Toluca | 4:4 |