| 3. Round | 30/07/2021 | Deportivo Municipal | - | Sporting Cristal | 1:1 |  |
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| 4. Round | 04/08/2021 | Sporting Cristal | - | Universitario de Deportes | 2:2 | ||||
| 5. Round | 06/08/2021 | Sport Huancayo | - | Sporting Cristal | 1:2 | ||||
| 6. Round | 14/08/2021 | Sporting Cristal | - | Universidad Cesar Vallejo | 0:1 | |
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| 8. Round | 23/08/2021 | Sporting Cristal | - | Cusco FC | 4:1 | ||||
| 9. Round | 27/08/2021 | FBC Melgar | - | Sporting Cristal | 0:1 | ||||
| 2. Round | 03/09/2021 | Sporting Cristal | - | Universidad San Martín | 1:1 | ||||
| 10. Round | 12/09/2021 | Sporting Cristal | - | Alianza Atlético | 5:2 | ||||
| 11. Round | 17/09/2021 | Universidad Técnica | - | Sporting Cristal | 1:6 | ||||
| 12. Round | 22/09/2021 | Sporting Cristal | - | Mannucci | 1:3 | ||||
| 13. Round | 27/09/2021 | Alianza Universidad | - | Sporting Cristal | 1:2 |  |
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| 14. Round | 01/10/2021 | Cienciano | - | Sporting Cristal | 2:1 | ||||
| 7. Round | 08/10/2021 | Deportivo Binacional | - | Sporting Cristal | 3:4 | ||||
| 15. Round | 17/10/2021 | Sporting Cristal | - | Ayacucho FC | 1:0 | ||||
| 16. Round | 24/10/2021 | Alianza Lima | - | Sporting Cristal | 1:3 |
Argentina
Chile