| 1. Round | 17/07/2010 | Sportivo Luqueño | - | Libertad | 1:2 | ||||
| 5. Round | 15/08/2010 | Club Olimpia | - | Libertad | 0:2 | ||||
| 13. Round | 09/10/2010 | Tacuary | - | Libertad | 0:1 | ||||
| 14. Round | 16/10/2010 | Libertad | - | Sport Colombia | 4:0 | ||||
| 16. Round | 24/10/2010 | Libertad | - | Club Olimpia | 2:2 | ||||
| 18. Round | 05/11/2010 | Guaraní | - | Libertad | 2:0 | ||||
| 22. Round | 05/12/2010 | Libertad | - | 3 de Febrero | 5:0 |  |
Uruguay