| 1. Round | 06/01/2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
| 3. Round | 18/01/2022 | Cancún FC | - | Dorados de Sinaloa | 1:2 | ||||
| 8. Round | 18/02/2022 | Atlético Morelia | - | Cancún FC | 4:1 | ||||
| 11. Round | 09/03/2022 | Venados FC | - | Cancún FC | 1:0 | ||||
| 12. Round | 16/03/2022 | Cancún FC | - | Tapatío | 1:0 | ||||
| 14. Round | 26/03/2022 | Cancún FC | - | Pumas Tabasco | 2:2 | ||||
| 17. Round | 13/04/2022 | Leones Negros | - | Cancún FC | 1:0 |
Mexico