| 2. Round | 06/07/2022 | Cancún FC | - | CF Monterrey II | 0:1 | ||||
| 3. Round | 14/07/2022 | Atlante | - | Cancún FC | 2:0 | ||||
| 4. Round | 20/07/2022 | Cancún FC | - | Coyotes de Tlaxcala | 1:0 | ||||
| 5. Round | 28/07/2022 | Cimarrones de Sonora | - | Cancún FC | 0:0 | ||||
| 6. Round | 03/08/2022 | Cancún FC | - | Atlético La Paz | 2:0 |  |
|||
| 7. Round | 12/08/2022 | Correcaminos UAT | - | Cancún FC | 0:0 | ||||
| 8. Round | 17/08/2022 | Cancún FC | - | Alebrijes de Oaxaca | 0:0 | ||||
| 9. Round | 25/08/2022 | Tapatío | - | Cancún FC | 1:0 | |
|||
| 10. Round | 31/08/2022 | Cancún FC | - | Venados FC | 1:2 | ||||
| 11. Round | 06/09/2022 | Leones Negros | - | Cancún FC | 3:0 | ||||
| 12. Round | 14/09/2022 | Cancún FC | - | Club Celaya | 0:4 | ||||
| 13. Round | 22/09/2022 | Atlético Morelia | - | Cancún FC | 0:0 | |
|||
| 14. Round | 26/09/2022 | Cancún FC | - | Dorados de Sinaloa | 1:2 | ||||
| 15. Round | 29/09/2022 | Cancún FC | - | Alacranes de Durango | 0:0 | ||||
| 16. Round | 07/10/2022 | Mineros de Zacatecas | - | Cancún FC | 4:0 | ||||
| 17. Round | 12/10/2022 | Cancún FC | - | Tepatitlán | 1:2 |
Mexico