| 1. Round | 08/01/2021 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 2:0 | ||||
| 2. Round | 17/01/2021 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 0:3 | ||||
| 3. Round | 22/01/2021 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 2:2 |  |
|||
| 4. Round | 29/01/2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 5. Round | 07/02/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 6. Round | 12/02/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 1:0 | ||||
| 7. Round | 19/02/2021 | FC Juárez [U20] | - | Mazatlán FC [U20] | 2:2 | ||||
| 8. Round | 26/02/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 9. Round | 03/03/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 2:2 | ||||
| 10. Round | 06/03/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 11. Round | 13/03/2021 | UANL Tigres [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 12. Round | 19/03/2021 | Mazatlán FC [U20] | - | CF América [U20] | 1:0 | ||||
| 16. Round | 23/04/2021 | Mazatlán FC [U20] | - | Club León [U20] | 1:3 | ||||
| 17. Round | 01/05/2021 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:0 |
Mexico