| 1. Round | 10/07/2016 | General Díaz | - | General Caballero ZC | 0:0 | ||||
| 2. Round | 17/07/2016 | General Caballero ZC | - | Guaraní | 0:1 | ||||
| 3. Round | 21/07/2016 | Club Olimpia | - | General Caballero ZC | 0:0 | ||||
| 4. Round | 25/07/2016 | General Caballero ZC | - | Club Rubio Ñu | 1:1 | ||||
| 9. Round | 29/08/2016 | General Caballero ZC | - | Sol de América | 2:1 | ||||
| 10. Round | 09/09/2016 | Club Nacional | - | General Caballero ZC | 4:1 | ||||
| 11. Round | 17/09/2016 | General Caballero ZC | - | Libertad | 1:5 | ||||
| 12. Round | 24/09/2016 | General Caballero ZC | - | General Díaz | 2:2 | ||||
| 14. Round | 16/10/2016 | General Caballero ZC | - | Club Olimpia | 2:3 | ||||
| 15. Round | 21/10/2016 | Club Rubio Ñu | - | General Caballero ZC | 0:1 | ||||
| 16. Round | 28/10/2016 | General Caballero ZC | - | Sportivo Luqueño | 0:1 | ||||
| 17. Round | 05/11/2016 | General Caballero ZC | - | River Plate | 1:0 | ||||
| 19. Round | 27/11/2016 | General Caballero ZC | - | Cerro Porteño | 1:1 |  |
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| 20. Round | 02/12/2016 | Sol de América | - | General Caballero ZC | 1:1 | ||||
| 21. Round | 11/12/2016 | General Caballero ZC | - | Club Nacional | 1:2 |
Ecuador