| 8. Round | 13/07/2021 | Blooming | - | Nacional Potosí | 2:1 | ||||
| 9. Round | 18/07/2021 | Oriente Petrolero | - | Blooming | 3:0 | ||||
| 23. Round | 24/10/2021 | Nacional Potosí | - | Blooming | 4:0 | ||||
| 24. Round | 28/10/2021 | Blooming | - | Oriente Petrolero | 1:1 | ||||
| 25. Round | 30/10/2021 | The Strongest | - | Blooming | 2:1 | ||||
| 26. Round | 21/11/2021 | Blooming | - | Jorge Wilstermann | 2:2 | ||||
| 27. Round | 27/11/2021 | Atlético Palmaflor | - | Blooming | 3:0 | ||||
| 28. Round | 01/12/2021 | Blooming | - | Always Ready | 1:2 |  |
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| 29. Round | 05/12/2021 | Royal Pari | - | Blooming | 4:3 | ||||
| 30. Round | 11/12/2021 | Blooming | - | Real Potosí | 1:0 |
Bolivia