| 1. Round | 09/01/2021 | UANL Tigres [U20] | - | Club León [U20] | 6:0 | ||||
| 2. Round | 18/01/2021 | Club León [U20] | - | CF Pachuca [U20] | 0:3 | ||||
| 9. Round | 02/03/2021 | Club León [U20] | - | Puebla FC [U20] | 2:1 | ||||
| 10. Round | 06/03/2021 | CF América [U20] | - | Club León [U20] | 0:1 | ||||
| 3. Round | 10/03/2021 | CF Monterrey [U20] | - | Club León [U20] | 0:0 | ||||
| 12. Round | 21/03/2021 | Santos Laguna [U20] | - | Club León [U20] | 3:0 | ||||
| 15. Round | 19/04/2021 | Club León [U20] | - | FC Juárez [U20] | 1:2 | ||||
| 16. Round | 23/04/2021 | Mazatlán FC [U20] | - | Club León [U20] | 1:3 | ||||
| 17. Round | 01/05/2021 | Club León [U20] | - | Gallos Blancos [U20] | 3:0 |
Mexico