| 3. Round | 24/05/2018 | Louisville City FC | - | Saint Louis FC | 1:0 | ||||
| 4. Round | 06/06/2018 | Louisville City FC | - | New England Revolution | 3:2 |  |
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| Round of 16 | 21/06/2018 | Louisville City FC | - | Nashville SC | 2:1 | ||||
| Quarter-finals | 19/07/2018 | Chicago Fire | - | Louisville City FC | 4:0 |
USA