| 2. Round | 12/01/2022 | TM Fútbol Club | - | Alebrijes de Oaxaca | 1:1 | ||||
| 3. Round | 20/01/2022 | Pumas Tabasco | - | TM Fútbol Club | 2:0 | ||||
| 4. Round | 27/01/2022 | TM Fútbol Club | - | Dorados de Sinaloa | 1:1 | ||||
| 5. Round | 30/01/2022 | Tapatío | - | TM Fútbol Club | 2:1 | ||||
| 6. Round | 03/02/2022 | TM Fútbol Club | - | Cancún FC | 1:2 | ||||
| 7. Round | 11/02/2022 | Atlante | - | TM Fútbol Club | 1:0 | ||||
| 8. Round | 16/02/2022 | Venados FC | - | TM Fútbol Club | 2:1 | ||||
| 9. Round | 23/02/2022 | TM Fútbol Club | - | Tepatitlán | 3:1 | ||||
| 10. Round | 04/03/2022 | Cimarrones de Sonora | - | TM Fútbol Club | 1:0 |  |
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| 11. Round | 09/03/2022 | TM Fútbol Club | - | CF Monterrey II | 0:0 | ||||
| 12. Round | 20/03/2022 | Atlético Morelia | - | TM Fútbol Club | 2:1 | ||||
| 13. Round | 24/03/2022 | TM Fútbol Club | - | Mineros de Zacatecas | 1:0 | |
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| 14. Round | 28/03/2022 | Correcaminos UAT | - | TM Fútbol Club | 2:1 | |
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| 15. Round | 02/04/2022 | Leones Negros | - | TM Fútbol Club | 1:1 | ||||
| 16. Round | 07/04/2022 | TM Fútbol Club | - | Club Celaya | 2:2 | ||||
| 17. Round | 12/04/2022 | Coyotes de Tlaxcala | - | TM Fútbol Club | 1:0 |
Mexico