1. Round | 08/01/2012 | Club San Luis | - | Pumas UNAM | 1:0 | ||||
2. Round | 14/01/2012 | Estudiantes Tecos | - | Club San Luis | 0:2 | ||||
3. Round | 21/01/2012 | Monarcas Morelia | - | Club San Luis | 2:0 | ||||
4. Round | 29/01/2012 | Club San Luis | - | CF América | 1:3 | ||||
5. Round | 04/02/2012 | CF Monterrey | - | Club San Luis | 3:0 | ||||
6. Round | 12/02/2012 | Club San Luis | - | UANL Tigres | 0:2 | ||||
7. Round | 19/02/2012 | Deportivo Guadalajara | - | Club San Luis | 0:0 | ||||
8. Round | 26/02/2012 | Club San Luis | - | Atlas Guadalajara | 0:1 | ||||
9. Round | 04/03/2012 | Santos Laguna | - | Club San Luis | 5:2 | ||||
10. Round | 11/03/2012 | Club San Luis | - | CF Pachuca | 0:0 | ||||
11. Round | 18/03/2012 | Puebla FC | - | Club San Luis | 0:1 | ||||
12. Round | 25/03/2012 | Club San Luis | - | Atlante | 2:3 | ||||
13. Round | 31/03/2012 | Cruz Azul | - | Club San Luis | 3:1 | ||||
14. Round | 08/04/2012 | Club San Luis | - | Jaguares Chiapas | 2:3 |