| 1. Round | 21/03/2021 | Blooming | - | CD Guabirá | 0:1 |  |
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| 3. Round | 03/04/2021 | Bolívar | - | Blooming | 2:0 | |
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| 4. Round | 10/04/2021 | Blooming | - | Club Aurora | 1:0 |  |
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| 5. Round | 25/04/2021 | Real Tomayapo | - | Blooming | 2:1 | ||||
| 6. Round | 04/05/2021 | Blooming | - | Club San José | 4:0 | ||||
| 7. Round | 07/05/2021 | Real Santa Cruz | - | Blooming | 1:0 | ||||
| 17. Round | 22/08/2021 | Independiente Petrolero | - | Blooming | 3:0 | ||||
| 18. Round | 15/09/2021 | Blooming | - | Bolívar | 2:2 | |
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| 19. Round | 18/09/2021 | Club Aurora | - | Blooming | 2:0 | ||||
| 20. Round | 22/09/2021 | Blooming | - | Real Tomayapo | 0:1 | ||||
| 21. Round | 25/09/2021 | Club San José | - | Blooming | 1:2 | ||||
| 22. Round | 18/10/2021 | Blooming | - | Real Santa Cruz | 3:1 | |
Bolivia