| 2. Round | 05/07/2022 | Royal Pari | - | Independiente Petrolero | 3:2 |  |
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| 4. Round | 16/07/2022 | Independiente Petrolero | - | Bolívar | 1:4 | ||||
| 5. Round | 25/07/2022 | Independiente Petrolero | - | Universitario de Sucre | 2:0 | ||||
| 6. Round | 30/07/2022 | Club Aurora | - | Independiente Petrolero | 1:0 |  |
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| 10. Round | 14/08/2022 | CD Guabirá | - | Independiente Petrolero | 1:1 | ||||
| 13. Round | 28/08/2022 | Independiente Petrolero | - | Always Ready | 1:1 | |
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| 14. Round | 31/08/2022 | Atlético Palmaflor | - | Independiente Petrolero | 2:1 | ||||
| 15. Round | 03/09/2022 | Independiente Petrolero | - | The Strongest | 1:1 | ||||
| 16. Round | 07/09/2022 | Universitario de Vinto | - | Independiente Petrolero | 4:1 | |
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| 17. Round | 11/09/2022 | Independiente Petrolero | - | Royal Pari | 3:0 | |
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| 18. Round | 18/09/2022 | Blooming | - | Independiente Petrolero | 1:0 | ||||
| 20. Round | 07/10/2022 | Universitario de Sucre | - | Independiente Petrolero | 2:1 | ||||
| 21. Round | 11/10/2022 | Independiente Petrolero | - | Club Aurora | 1:1 | ||||
| 22. Round | 13/10/2022 | Oriente Petrolero | - | Independiente Petrolero | 3:3 | ||||
| 24. Round | 21/10/2022 | Independiente Petrolero | - | Real Tomayapo | 1:0 |
Bolivia